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Symptoms affecting the nervous system or mental function are more difficult to diagnose and may escape detection due to the low specificity of the symptoms and the limited time available for each patient in primary care settings

Collectively, the roadmap toward clinical translation should include systematic human safety and pharmacokinetic studies, biomarker-driven and phenotype-stratified randomized controlled trials, rigorous exploration of combination regimens, and incorporation of patient-centered outcomes

Patients have to experience a minimum of 15 headaches or more lasting four hours a day or longer per month, according to the FDA

Adequate B12 ensures optimal oxygen transport throughout the body, directly impacting energy levels and physical endurance